Years active
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Over two decades of open-source development for mass spectrometry workflows.
Open-source · Free forever
Open science. Clear results for mass spectrometry.
An expert-crafted ecosystem of computational mass spectrometry tools — run vetted apps,build on open algorithms, and join the community.
Ready-to-use apps Modular workflows Built by the community
Citations
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Peer-reviewed research citing OpenMS tools and algorithms worldwide.
Contributors
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Developers, researchers, and community members advancing OpenMS worldwide.
Community tools
Featured Apps
Apps are scientifically validated end-to-end solutions for common proteomics and metabolomics analysis. Test online, then download and deploy locally.
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FLASH App
Web-based analysis and visualization of top-down proteomics data
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OpenDIAKiosk
Interactive DIA proteomics data analysis
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umetaflow
Web-based access to the umetaflow pipeline
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OpenDDA
Web-based workflow for DDA proteomics
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naseweis
Web-based access to the nucleic acid search engine (NASE)
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NuXL
Web-based analysis pipeline for XL-MS data
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MHCquant
Web-based analysis pipeline for immunopeptidomics
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Adopted by labs and institutions worldwide.
What is OpenMS?
The open-source LC-MS library
A C++ core with Python bindings for LC/MS data management, analysis, and visualization—built for rapid development of mass spectrometry software.
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Open source
Core library and tools you can extend, share, and ship under a three-clause BSD license.
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C++ & Python
High-performance algorithms with pyOpenMS for scripting and workflows.
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Cross-platform
Build and run on all major platforms with the same toolchain.
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TOPP pipeline
Ready-made command-line utilities for proteomics and metabolomics analysis.
Developer tools
Ecosystem
Build your own pipelines using our ecosystem
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C++ library
OpenMS-lib
Reusable C++ algorithms and data structures for mass spectrometry software. Ships with The OpenMS Pipeline (TOPP) command line tools for mass spectrometry analysis.
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Python
pyOpenMS
Python bindings to OpenMS-lib. Write custom analysis scripts and integrate OpenMS into Python workflows.
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Web apps
OpenMS-Web apps
Web interface template for OpenMS pipelines. Deploy custom analysis tools as interactive web apps without frontend development.
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Visualization
pyopenms_viz
Visualization library for mass spectrometry data. Create interactive and static plots directly from Python dataframes.
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Community
Everyone is welcome
OpenMS is built by a diverse group of contributors around the world. Whether you are new to mass spectrometry or a seasoned developer, there is a place for you in our community.
We are committed to being open, inclusive, and welcoming — read the Code of Conduct for how we work together.
Latest news
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Workshop at University of Helsinki on April 30th 2026.
We are teaching a one-day workshop on MS analysis with OpenMS and OpenDIAKiosk at the University of Helsinki on April 30th 2026. Click the header above for more …
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2026 Recipient Announced: Rising Star in Computational Mass Spectrometry
OpenMS announces Maria Llambrich Rodriguez as the 2026 Rising Star in Computational Mass Spectrometry recipient.
Upcoming events
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OpenMS Autumn Workshop
Hands-on training on proteomics and metabolomics workflows with OpenMS and TOPP tools.
Tübingen, Germany
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OpenMS Developer Meeting 2027
Annual developer meeting with tutorials, talks, and code sprints.
To be announced
Contact
Take control of your mass spec workflows today
Tell us about your pipeline, integrations, or tooling goals — we will point you to the fastest next step.